Cilo Cybin Sleep

The Cilo Cybin SLEEP is scientifically formulated to focus primarily on inducing sleep effects via the Endocannabinoid System (ECS).
The product consists of full plant broad-spectrum cannabis extracts with an adjusted terpene profile which targets the major cannabinoid metabolites and their pathways in order to promote and induce sleep. The formulation is made more bio-available through a self emulsifying drug delivery system.
This synergy of mechanisms creates what is often referred to as an entourage of effects which assists the ECS to accomplish and maintain homeostasis.

Traditional CBD and THC are mixed with delivery oils such as MCT, Olive, Sesame oil, etc. A delivery system mixes with CBD and THC to allow it to be flowable, but at the same time to act as the carrier of CBD and THC into your system. When using oils like  the above the bioavailable is around 3-6% bioavailable. 

Bioavailability is the extent to which absorption occurs. In other words, bioavailability is the fraction of the administered drug that reaches the systemic circulation in the unchanged form. The intravenous route lacks a phase of absorption as the drug is directly injected into the systemic circulation.

Self-emulsifying drug delivery system (SEDDS) is a kind of solid or liquid formulation composed of drugs, oil, surfactant and cosurfactant. It could form a fine emulsion (micro/nano) in the gastrointestinal tract after oral administration. Later on, the formed emulsion is absorbed through the lymphatic pathway. The oral bioavailability of drugs in SEDDS would be improved for bypassing the first-pass effect of the liver. Therefore, SEDDS has become a vital strategy to increase the oral bioavailability of poor water-soluble drugs.

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